I use Mozy, which is IMHO a better solution.
there are some compassions between them on the web. Mozy is always the best options.
(I started using Mozy following Scott Hansleman recommendation)
I use also Carbonite for more then a year now. It's really great. Last week I visited TechEd Barcelona and my data folder was not updated for a week. The next Monday I've got a message of Carbonite that my backup has not run for a week... Little things what makes this product really great.
And... Unfortunately I needed to test the restore function a couple of times ...and it worked :-) Carbonite is my lifesaver!
I liked MyOtherDrive's interface much better than Carbonite's, and at free I love the price, but MyOtherDrive doesn't have the Explorer menu that lets me backup automatically.